History of Dermal and Subdermal Injectable Fillers Before Collagen: The Early Years

Dermal fillers are a mainstay of aesthetic medicine. Currently, the most common ingredient in fillers is hyaluronic acid (HA). However, there was an evolution of products that brought us to where we are today. We review the fillers from fat to synthetic fillers in this review paper. We present notable figures in history who used such fillers and key legislation on the use of such fillers. The early evolution of the use of volumization has been reviewed. This is an important milestone in the history of fillers that is rather brief in the present literature.