• Title of article

    Association Study of rs1333040 and rs1004638 Polymorphisms in the 9p21 Locus with Coronary Artery Disease in Southwest of Iran

  • Author/Authors

    Golabgir Khademi , Khadijeh Dept. of Genetics - Faculty of Science - Shahid Chamran University of Ahvaz - Ahvaz, Iran , Foroughmand, Ali Mohammad Dept. of Genetics - Faculty of Science - Shahid Chamran University of Ahvaz - Ahvaz, Iran , Galehdari, Hamid Dept. of Genetics - Faculty of Science - Shahid Chamran University of Ahvaz - Ahvaz, Iran , Dinarvand , Parvaneh Dept. of Genetics - Faculty of Science - Shahid Chamran University of Ahvaz - Ahvaz, Iran , Shahbazi, Zahra Dept. of Genetics - Faculty of Science - Shahid Chamran University of Ahvaz - Ahvaz, Iran , Yazdankhah , Saied Dept. of Medicine - Jondi Shapour University of Medical Science - Ahvaz, Iran , Pourmahdi Borujeni , Mahdi Dept. of Food Hygiene - Faculty of Veterinary medicine - Shahid Chamran University of Ahvaz - Ahvaz, Iran

  • Pages
    6
  • From page
    122
  • To page
    127
  • Abstract
    Coronary artery disease (CAD) is a multifactorial and heterogenic disease. Recently, genome-wide association studies have reported that rs1333040 (C/T) and rs1004638 (A/T) single nucleotide polymorphisms (SNPs) in the 9p21 locus have very strong association with CAD. This study aimed to examine these associations in Southwest of Iran. Methods: Blood samples were collected from 200 CAD patients and 110 healthy individuals with no CAD. The association of two SNPs with CAD was evaluated by PCR and restriction fragment length polymorphism. Results: Chi-square test showed no association between rs1333040 SNP and CAD (X2: 4.66, df: 2, P=0.09). Also, there was no association between rs1004638 SNP and CAD (X2: 0.27, df: 2, P=0.88). Conclusion: No association was observed between rs1333040 and rs1004638 SNPs in the 9P21 region and CAD in Southwest of Iran.
  • Keywords
    Genetic association study , Iran , Single nucleotide polymorphisms , Coronary artery disease
  • Journal title
    Iranian Biomedical Journal(IBJ)
  • Serial Year
    2016
  • Record number

    2524896

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=2524896