Title of article
Synthesis and in vitro antimycobacterial activities of novel 6-substituted-3(2H)-pyridazinone-2-acetyl-2- (substituted/nonsubstituted acetophenone) hydrazone
Author/Authors
UTKU, Semra Mersin University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, TURKEY , GÖKCE, Mehtap Gazi Üniversitesi - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, TURKEY , ASLAN, Gönül Mersin University - Faculty of Medicine - Department of Medical Microbiology, TURKEY , BAYRAM, Gül Mersin University - Health Services Vocational School, TURKEY , ÜLGER, Mahmut Mersin University - Faculty of Medicine - Department of Medical Microbiology, TURKEY , EMEKDAS, Gürol Mersin University - Faculty of Medicine - Department of Medical Microbiology, TURKEY , SAHIN, M. Fethi Gazi Üniversitesi - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, TURKEY
From page
331
To page
339
Abstract
The difficulty in managing tuberculosis includes the prolonged duration of the treatment, the emergence of drug resistance, and coinfection with HIV/AIDS. Tuberculosis control requires new drugs that act on novel drug targets to help in combating resistant forms of Mycobacterium tuberculosis and reduce the treatment duration. For this purpose, 6-substituted-3(2H) -pyridazinone-2 -acetyl-2-(substituted/nonsubstituted acetophenone) hydrazone derivatives were synthesized and their structures were elucidated by elemental analyses, IR, and 1H-NMR. The in vitro antimycobacterial activities of synthesized compounds 5a-l were determined by the agar proportion method against Mycobacterium tuberculosis H37Rv. Among the target compounds, 5b and 5f exhibited the best antimycobacterial activity, with a MIC value of 5 μg/mL.
Keywords
3(2H) , Pyridazinone , acetophenone hydrazone , antimycobacterial activity , antitubercular drugs
Journal title
Turkish Journal of Chemistry
Journal title
Turkish Journal of Chemistry
Record number
2533089
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