Title of article
Transient abnormal myelopoeisis in newborns with Down syndrome
Author/Authors
Zarina, AL Universiti Kebangsaan Malaysia - Faculty of Medicine - Departments of Paediatrics, Malaysia , Hamidah, A Universiti Kebangsaan Malaysia - Faculty of Medicine - Departments of Paediatrics, Malaysia , Yong, SC Universiti Kebangsaan Malaysia - Faculty of Medicine - Departments of Paediatrics, Malaysia , Rohana, J Universiti Kebangsaan Malaysia - Faculty of Medicine - Departments of Paediatrics, Malaysia , Hamidah, NH Universiti Kebangsaan Malaysia - Faculty of Medicine - Departments of Pathology, Malaysia , Azma, RZ Universiti Kebangsaan Malaysia - Faculty of Medicine - Departments of Pathology, Malaysia , Boo, NY Universiti Kebangsaan Malaysia - Faculty of Medicine - Departments of Paediatrics, Malaysia , Jamal, R Universiti Kebangsaan Malaysia - Faculty of Medicine - Departments of Paediatrics, Malaysia
From page
107
To page
111
Abstract
Transient abnormal myelopoeisis (TAM) is a haematological phenomenon commonly seen in newborns with Down syndrome. Although the majority show spontaneous resolution, this condition should not be dismissed too readily as there have been associated fatalities. Furthermore, even for those who do show spontaneous resolution, a significant percentage will develop acute megakaryoblastic leukaemia within the next few years of life. We report a series of four patients with TAM who presented with hepatosplenomegaly and leucocytosis detected on preliminary investigations.
Keywords
transient abnormal myelopoeisis , Down syndrome
Journal title
The Malaysian Journal of Pathology
Journal title
The Malaysian Journal of Pathology
Record number
2537564
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