Alteration of Hematological and Plasma Physiological Parameters Following a Standard Protocol of General Anesthesia: A Pilot Study in Assiut University Hospitals

The objective of this study was to evaluate the effects of a standard anesthetic protocol using Propofol, fentanyl, and Sevoflourane, on hematological and plasma physiological variables in humans. Blood samples were collected from fourteen (14) individuals undergoing surgery for a complete blood count (CBC) before and after the induction of anesthesia. Plasma physiological parameters as creatinine, urea, and blood glucose level were also measured. Hemoglobin concentration, showed a significant decrease after anesthesia induction (p 0.0001). There was also a significant decrease in the red blood cell (RBC’s) count and hematocrit values (p 0.001 p 0.05 respectively). Total leucocytic count (TLC) and platelets exhibited a non-significant reduction. Serum creatinine significantly reduced (p 0.0001) after the induction of anesthesia while blood urea significantly increased (p 0.001). There was a non-significant increase in blood glucose level. This study suggests that a careful monitoring during anesthesia is advisable to avoid possible postoperative life threatening complications.