Title of article
Novel Potentiometric Determination of Torasemide for Antidoping Purpose, Using B-Cyclodextrin and Calixarene
Author/Authors
El-Kosasy, Amira, M. Ain Shams university - bPharmaceutical Analytical Chemistry Department, Faculty of pharmacy, Ain Shams university, Abbassia, Cairo, Egypt, Egypt , El-Aziz, Omar, Abd Pharmaceutical Analytical Chemistry Department, Faculty of pharmacy, Ain Shams, university, Abbassia, Cairo, Egypt, Egypt , Ebrahim, Naglaa Pharmaceutical Analytical Chemistry Department, Faculty of pharmacy, Ain Shams,university, Abbassia, Cairo, Egypt, Egypt , Fattah, Laila, Abdel Pharmaceutical Analytical Chemistry Department, Faculty of pharmacy, Misr university for science and technology,6thOctober, Giza, Egypt, Egypt
From page
357
To page
371
Abstract
Two novel Torasemide (TOR) sensors were investigated, using B-cyclodextrin and calix[4]arene as ionophores, where linear responses within concentration ranges of (10-7-10-2 and 10-8-10-2M) and Nernstian slopes of (58.77 and 59.214 mV/decade) over the pH range of 7-12 were obtained, respectively.The selectivity coefficients of the developed sensors indicate excellent selectivity for TOR, where the second sensor shows a higher sensitivity if compared to the first one. The proposed fabricated sensors display useful analytical characteristics for the determination of TOR (for anti-doping purpose) in bulk powder, biological fluids and in pharmaceutical formulation.
Keywords
Torasemide , B , cyclodextrin , Calix[4]arene , Potentiometry , Antidoping , Plasma , Urine ,
Journal title
Analytical and Bioanalytical Electrochemistry
Journal title
Analytical and Bioanalytical Electrochemistry
Record number
2541494
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