Effects on the Maternal Nausea and Vomiting after Giving Prophylactic Ephedrine Versus Phenylephrine for Prevention of Hypotension in Severe Pre-Eclamptic Parturients Uundergoing Cesarean Section Under Spinal Anesthesia

Objective: Is to compare the incidence of of nausea and vomiting after giving phenylephrine and ephedrine for the prevention of spinal anesthesia induced hypotension in severe preeclamptic patients undergoing cesarean delivery.Methods: 60 severely pre-eclamptic patients randomly allocated into 2 equal groups (30 patients each) using computer generated numbers and concealed using sequentially numbered, sealed opaque envelope technique.Group E (ephedrine): Patients received bolus of 10 milligram of ephedrine i.v immediately after the subarachnoid block.Group P (phenylephrine): Patients received bolus of 100 microgram of phenylephrine i.v immediately after the subarachnoid block.Nausea and vomiting were observed, recorded preoperative, intraoperative and postoperative. They were treated by atropine if occurred intraoperative or ondansetron if occurred postoperative.Results: Intraoperatively, in ephedrine group, four patients suffered from nausea and one patient suffered from vomiting and they were treated by 0.5mg atropine. While in phenyle-phrine group, no patients suffered from nausea or vomiting.Conclusion: Ephedrine administration is associated with higher incidence of nausea and vomiting in the mother.