Fundus Autoflu ores cence Findings Pre and Post Intravitreal Bevacizumab Injection in Patients with Diabetic Macular Edema

Purpose: Tо evaluate fundus autofluorescence patterns in cases of diabetic macular edema prior to and following intravitreal injections of bevacizumab. Design: Prospective interventional study. Methods: Forty eyes with non-ischemic cystoid or diffuse macular edema underwent SW-FAF imaging prior to and after three intravitreal injections of bevacizumab and the pattern of hyperautofluorescence was determined (number and total area of hyperautofluorescent spots). SD-ACT was done to determine the СFT, integrity of the 13/0S junction and other visually significant findings. Results: 35 cases (87.5%) had abnormal foveal hyperautofluorescence: Four showed a single spot of hyperautofluoгescence (11.4%) and 31 showed multiple spots (88.6%). The total area of hyperautofluorescent spots was significantly greater for single than multiple spots both pre and post injection. On subdivision of cases into groups according to the change in their BCVA, the improved viusal acuity group had less hyperautofluorescent spots and a slightly greater total area of hyperautofluorescence. Conclusion: There are certain FAF patterns in DMB, but they cannot be definitively correlated with prognosis following therapy.