Estrogen Effect to Expression of Calcitonin Gene Related Peptide, Protein Gene Product 9.5, and Tyrosine Hydroxylase in Vaginal Epithelial Mucous of Wistar Mouse with Ovariectomy Bilateral

Background: To know role of CGRP, PGP 9.5, and TH to pathogenesis mechanism of change in vaginal epithelial mucous of Wistar mouse with decreases estrogen level. Method: Randomized posttest only control group design. Treatment group is wistar mouse post bilateral ovariectomy that given estrogen. Control group is wistar mouse post bilateral ovariectomy that not given estrogen. Results: We use 34 sample of Wistar mouse (Rattus norvegicus) and divided further to 2 group of 17 treatment mouse and 17 control group. We analyzed expression CGRP, PGP 9.5, and TH in both group. It Shown CGRP expression in control group significantly different compared with treatment group, PGP 9.5 expression in control group higher compared to treatment group, TH expression of control group higher compared to treatment group. Conclusion: Estrogen decreased expression of CGRP, PGP 9.5, and TH. CGRP is the most affected by estrogen compared to PGP 9.5 and TH.