Title of article
Synthesis and anti-histaminic activity of some novel pyrimidines
Author/Authors
Rahaman, Sk.A. KVSR Siddhartha College of Pharmaceutical Sciences - Department of Pharmaceutical Chemistry, India , Pasad, Y. Rajendra Andhra University - University College of Pharmaceutical Sciences, India , Kumar, Phani Andhra University - University College of Pharmaceutical Sciences, India , Kumar, Bharath Andhra University - University College of Pharmaceutical Sciences, India
From page
255
To page
258
Abstract
Novel pyrimidines were prepared by the condensation of chalcones of 40-piperazine acetophenone with guanidine HCl. The structures of the synthesized compounds RP 1–5 were assigned on the basis of elemental analysis, IR, 1H NMR and mass spectroscopy. These compounds were also screened for anti-histaminic activity. The recorded percentage of histamine inhibition showed a significant anti-histaminic activity when compared to the reference anti-histaminic drug mepiramine
Keywords
Pyrimidine , Chalcone , Anti , histaminic activity
Journal title
Saudi Pharmaceutical Journal(SPJ)
Journal title
Saudi Pharmaceutical Journal(SPJ)
Record number
2552592
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