Title of article
Biological Activities of Four Melicope Species(Aktiviti Biologi bagi Empat Spesies Melicope)
Author/Authors
HASHIM, NAJIHAH MOHD Universiti Putra Malaysia - Department of Chemistry, Malaysia , RAHMANI, MAWARDI Universiti Putra Malaysia - Department of Chemistr, Malaysia , MOHD ISMAIL, HAZAR BEBE university of malaya - Centre for Foundation Study in Science, Malaysia , ASPOLLAH SUKARI, MOHD Universiti Putra Malaysia - Department of Chemistry, Malaysia , MANAF ALI, A. Universiti Putra Malaysia - Department of Biotechnology, Malaysia , EE CHENG LIAN, GWENDOLINE Universiti Putra Malaysia - Department of Chemistry, Malaysia
From page
767
To page
771
Abstract
The leaves and stem barks extracts of four plant species, Melicope confusa, M. clemensiae, M. lunu-ankenda and M. latifolia were screened for their antimicrobial, antioxidant and cytotoxic activities. Almost all extracts of M. clemensia exhibited moderate growth inhibition when tested against the three pathogenic fungi. However, when tested against pathogenic bacteria, the three leaves extracts showed strong activity against methicillin resistant S. aureus and moderate for the other bacteria. In the antioxidant assay by using DPPH, the three leaves extracts of M. lunu-ankenda exhibitedsignificant activity with with IC50 values of 7.8, 15.6 and 7.8 μg/mL. In addition, the petroleum ether leaves extract of M. clemensiae and the chloroform leaves extract of M. lunu-ankenda showed strong cytotoxic activity when tested against human promyelocytic leukemia (HL60) cell line with IC50 values of 2.8 and 0.8 μg/mL, respectively.
Keywords
Antioxidant antimicrobial , cytotoxic , M. clemensiae , M. lunu , ankenda , M. latifolia , Melicope , confusa
Record number
2554773
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