Title of article
Pharmacokinetics of a Mono-pyridinium-mono-aldoxime (K-347), a Potential Antidote in Organophosphate Poisoning
Author/Authors
Kalász, Huba Department of Pharmacology and Pharmacotherapy - Semmelweis University - Budapest, Hungary , Karvaly, Gellért Department of Laboratory Medicine - Semmelweis University, Budapest, Hungary , Szimrók, Ferenc Department , Szabó, Dóra Department of Medical Microbiology - Semmelweis University - Budapest, Hungary , Milánkovits, Márton Department of Medical Microbiology - Semmelweis University - Budapest, Hungary , Keglevich, András Department of Pharmacology and Pharmacotherapy - Semmelweis University - Budapest, Hungary , Adeghate, Jennifer Department of Ophthalmology - University of Pittsburgh, Pittsburgh, USA , Darvas, Ferenc ComInnex Inc. - 1031 Budapest, Hungary , Kuca, Kamil Department of Chemistry - Faculty of Science - University of Hradec Kralove - 500 03 Hradec Kralove, Rokitanskeho 62, Czech Republic , Musilek, Kamil Department of Chemistry - Faculty of Science - University of Hradec Kralove - 500 03 Hradec Kralove, Rokitanskeho 62, Czech Republic , Tekes, Kornélia Department of Pharmacodynamics - Semmelweis University - Budapest, Hungary
Pages
9
From page
99
To page
107
Abstract
Background:
Our recent work has been treating the pharmacokinetics of pyridinium aldoximes of various structures including their time-dependent distribution in the body of male rats and also the extent of blood-brain-barrier penetration.
Objective:
Our overall aim was to find a proper antidote in organophosphate poisoning with fast elimination.
Methods:
White male Wistar rats were intramuscularly injected with the aqueous solution of 3 µmol of K-347. The animals were sacrificed at different time periods following treatment; various tissues and body fluids were taken and homogenised. The level of K-347 was determined using reversed-phase HPLC. Dose-dependence of tissue level was also determined by using various doses, 3 µmol through 100 µmol of K-347.
Results:
The serum level of K-347 showed a definitely fast decline. K347 did not have any effect on Gram-positive and Gram-negative bacteria that we tested.
Conclusion:
The kinetics of K-347 showed an extremely fast offset, even in comparison with several other pyridinium aldoximes in clinical practice and in developmental stages.
Farsi abstract
فاقد چكيده فارسي
Keywords
Pharmacokinetics , K-347 , Time-dependence , Dose-dependence , Mono-pyridinium , Fast elimination , Absence of antibacterial effects
Journal title
Open Medicinal Chemistry Journal
Serial Year
2020
Full Text URL
Record number
2559603
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