In vitro α-glucosidase inhibitory activity of Monascus-fermented durian seed extracts

Study on the in vitro α-glucosidase inhibitory activity of Monascus-fermented durian seed extracts was carried out by inoculating the spore suspension of Monascus sp. KJR2 into boiled durian seed cuts and then incubated at room temperature for 14 days. The durian seed (DS) and powdered Monascus-fermented durian seed (MFDS) were extracted with distilled water and ethanol. The extracts were analyzed for the in vitro α-glucosidase inhibition activity and total phenol content. The results show that DS and MFDS ethanolic extracts have α-glucosidase inhibitory activity with IC50 of 199.1μg/mL and 70.7μg/mL, respectively. Water extract of DS and MFDS have low α-glucosidase inhibitory activity ( 10%). The total phenol contents of MFDS extracts were higher than that of DS extracts. MFDS is potential for diabetes mellitus management.