Dyslipidemias in normotensive and hypertensive individuals

The present work was carried out to compare the effects of age and antihypertensive therapy on lipid profile in hypertensive and normotensive individuals. A total of 150 individuals were used for the study.100 hypertensive under therapy were used and 50 normotensive served as control. Serum lipid (Cholesterol (T -chol) , triglyceride (TG), Phospholipids (PL),High density lipoprotein( HDL-chol ), Low density lipoprotein( LDLchol) and very low density lipoprotein (VLD L- chol) were biochemical parameters monitored. The normotensive studied had mean age of 50 ± 11 years and blood pressure of 117 ± 6 / 77± 6 mmHg. The hypertensive had mean age of 55 ± 10 years and blood pressure of 177±25 /103 ± 10 mmHg.The study revealed that there was a highly significant effect of age on total cholesterol in hypertensive than normotensive individuals .The mean total cholesterol (T -chol) and triglyceride (TG) were (156±11, and 59 ± 4) mg/dl respectively for the normotensives; and hypertensive the means were 166 ± 13 for the T –chol and 66± 7 mg/dl for triglyceride (P 0.05). Similarly, a significant lower phospholipids level of 158+8 mg /dl was obtained for normotensives, hypertensives had a mean (165± 11 mg/dl, P 0.05). However, HDL-chol was lower in hypertensives (57± 10) mg/dl than in normotensives (64± 13) mg/dl). Hypertensive patients also recorded higher mean values of LDL-chol (95+ 17) mg/dl than the normotensives with mean values of 81± 15 mg/dl for LDL- chol. Marginally higher level of VLD L- chol was observed in hypertensive patients as well compared to normotensive individuals VLD L- chol(13± 2)mg/dl and 12 ± 1 mg/dl for VLD Lchol( P 0.05).