Antihyperglycemic and Glucose Tolerance Activity of Ficus deltoidea Ethanolic Extract in Diabetic Rats

Ficus deltoidea or Mas cotek is one of the common medicinal plants used in Malaysia has been claimed to have antidiabetic activity. However, scientific evidence to confirm its efficacy is still lacking. Thus, the present study was undertaken to evaluate the potential ofethanolic extract ofFicus deltoidea to reduce hyperglycaemia in streptozotocininduced diabetic rats at different prandialstate. The results showed that, ethanolic extract ofFicus deltoidea significantly reducedfasting and postprandial hyperglycemia particularly after 4 and 6 hours ofextract administration. Likewise, glucose tolerance activity was significantly improved in the presence ofFicus del toidea ethanolic extract at a low dose, 100 mg/kg. It is suggested that ethanolic extract ofFicus deltoidea at particular doses, possessfasting andpostprandial antihyperglycemic activity as well as glucose tolerance activity in streptozotocin-induced diabetic rats.