Serous Pigment Epithelium Detachment Associated with Age-Related Macular Degeneration:A Possible Treatment Approach

To evaluate the effects of intravitreal triamcinolone acetonide (TA) as a monotherapy of serous PigmentEpithelial Detachment (PED) associated with AMD (Age-Related Macular Degeneration), this study has beenperformed. Seventeen patients (19 eyes) with serous PED associated with AMD were observed. All patientsreceived 0.1ml (4mg) of intravitreal TA. The mean follow-up period was 18 months. Re-attachment ofserous PED was observed in 37% of cases to the end of follow-up. In other cases, the height and length ofserous PED significantly decreased. Visual acuity remained stable in all cases. No evidence of RPE tear orCNV development were noted. Before TA administration, intraocular pressure (IOP) was 20.18 ± 2.58mmHg however, after intravitreal TA, IOP increased gradually and reached its maximum of all period ofobservation (23.25±1.85mmHg) six months after injection (P=0.031). In 7 (37%) of the cases, progression tocataract was observed after treatment. After surgery, the visual acuity in all cases increased by 0.2 to 0.5.As a conclusion, intravitreal TA decreases of both the height and length of serous PED associated with AMDafter 18 months follow-up in most cases. The presented data provides support for the hypothesis regardingthe possibility of monotherapy of serous PED with intravitreal TA.