Association of Blood Zinc with Reproductive Hormones Seminal Cytology

Background: Male infertility, which is attributable to many factors, out of which Zinc has been shown to play a role in reproduction and its deficiency, has been linked with male sterility and sub-fertility. Objective: The present study was designed to determine the serum level of blood Zn, semen cytology reproductive hormones in normal and sub-fertile individuals, with an objective to establish its association in such patients or otherwise. Study design: Descriptive analytical. Sampling technique: non-probability sampling Place Duration of Study: The present study was carried out in the Department of Reproductive physiology/Health, Public Health Laboratories Division, National Institute of Health, Islamabad and compiled in the Department of Biochemistry, Bannu Medical College, Bannu in 2012. Results: The result showed that blood Zn was 106.35± 4.29, 92.34 ± 3.90, 82.73± 2.73, 105.54± 6.85, 73.38± 2.74, 101.28± 5.33, 109.34± 5.31 and 139.97± 9.49 respectively while, LH was 16.35±1.12, 10.23±0.33, 8.96±0.26, 11.40±0.57, 11.14±1.01, 5.64±0.19,6.33±0.45,6.54±0.33, FSH was 27.53±, 13.60±0.96, 11.11±0.71, 17.27±1.71, 16.40±1.71, 5.22±0.23, 6.79±0.62, 6.54±0.55 and Testo was 4.53±0.25, 4.27±0.17, 4.31±0.12, 3.82±0.21, 4.09±0.18, 4.40±0.12, 6.34±0.57, 4.70±0.20 respectively in azoospermic, oligozoospermic, asthenozoospermic, oligoasthenozoospermic, teratozoospermic, normozoospermic, polyzoospermic and proven father groups. Comparing values of blood zinc in various groups, it was seen that highest values were recorded in case of proven fathers, moreover, blood Zn levels of all groups varied significantly (p 0.05) with proven fathers. Similarly, comparing LH FSH, highest values were recorded in Azoospermic group followed by oligozoospermic, while Testosterone in polyzoospermic group. Comparing values with proven fathers all were significant except polyzoospermic in FSH cases. Conclusion: In conclusion, it has been observed in our study that hypo level of zinc in serum (hypozincemia) causes hypogonadism, and arrest of spermatogenesis, which affect sperm count and sperm motility, and ultimately leads to male infertility.