Title of article
The Flavonoid Hesperetin Alleviates Behavioral Abnormality in 6-Hydroxydopamine Rat Model of Hemi-Parkinsonism
Author/Authors
Baluchnejadmojarad, Tourandokht tehran university of medical sciences tums - School of Medicine - Department of Physiology, تهران, ايران , Roghani, Mehrdad shahed university - School of Medicine , Medicinal Plant Research Center - Department of Physiology, تهران, ايران
From page
20
To page
23
Abstract
Parkinson’s disease (PD) is a neuropathological and debilitating disorder involving the degeneration of mesencephalic dopaminergic neurons. Neuroprotective effect of hesperetin has already been reported, therefore, this study examined whether the administration of this flavonoid would attenuate behavioral abnormalities in an experimental model of PD in rat. For this purpose, unilateral intrastriatal 6-hydroxydopamine (6-OHDA, 12.5 μg/5μl of saline-ascorbate)-lesioned rats were pretreated i.p. with hesperetin (10 mg/kg). It was found out that hesperetin administration attenuates the rotational behavior in lesioned rats. In summary, hesperetin administration attenuates behavioral abnormality in hemiparkinsonian rats and this may be of benefit, along with other therapies, in neurodegenerative disorders including PD
Keywords
Hesperetin , Parkinson’s Disease , 6 , hydroxydopamine , Rotational Behavior
Journal title
Basic and Clinical Neuroscience
Journal title
Basic and Clinical Neuroscience
Record number
2580599
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