Hydrolyse comparée dans les milieux homogène et hétérogène de la N-(m,p)-vinylbenzylidène-p-anisidine et de ses copolymères. Effet Retard (Comparative hydrolysis in homogeneous and heterogeneous media of N-(m, p)-vinylbenzylidene-p-anisidine and its copolymers. Drug Release Effect)

The present paper exposes a comparative drug release study of the p-anisidine (pAN) at 37°C as molecule model, grafted on the monomer N-(m,p)-vinylbenzylidene-p-anisidine (Im) and of its two copolymers (Cp1) and(Cp2) copolymerized whith N,N-dimethylacrylamide (DMA). This drug release was carried out into two différent média (m1) and (m2): Homogeneous hydroethanolic media (80% in volume with ethanol) at pH = 4.7 (m1). Heterogeneous aqueous media pH = 4.0 (m2): where (Im), (Cp1) and (Cp2) are insoluble, then dispersed under solid form. The kinetics of drug release can be described by a simple and classical kinetic equation (apparent order reaction n=1) in (m1) and not in (m2), where the process can be considered as being controlled by diffusion (Fick`s laws).The comparison of these two studies showed us, for the same time of immersion the drug releases is more important in (m2) compared to (m1), where the quantities of (pAN) released are not only weaker but appear at longer intervals of time