Induction of depigmentation in a universal vitiligo patient with combination of cryotherapy and phenol

13-year-old boy presented with vitiligo for last 5 years, which had slowly progressed to universal type except for a few macules on face. Topical monobenzylether of hydroquinone (MBEH) 20%, liquid nitrogen cryotherapy, phenol 88% and frequency-doubled Nd:YAG Q-switched laser had been used separately without any benefit. To resolve this problem, a combination of liquid nitrogen cryotherapy along with phenol 88% was planned. After single session, the patient responded to this method with complete depigmentation without any complication. We suggest that the combination of liquid nitrogen cryotherapy and phenol 88% for depigmentation of remaining normal pigmented skin in universal vitiligo, can be safe and cost-effective