Title of article
A Sub-Chronic Toxicity Study of Mercuric Chloride in the Rat
Author/Authors
Oriquat, Ghaleb A. Al-Ahliyya Amman University - Faculty of Pharmacy and Medical Sciences, Jordan , Saleem, Tahia H. Assiut University - Faculty of Medicine - Department of Medical Biochemistry, Egypt , Naik, Rajashri R. Al-Ahliyya Amman University - Faculty of Pharmacy and Medical Sciences, Jordan , Moussa, Said Z. Cairo University - Faculty of Veterinary Medicine - Department of Biochemistry, Internal Medicine, Egypt , Al-Gindy, Reda M. Cairo University - Faculty of Veterinary Medicine - Department of Biochemistry, Internal Medicine, Egypt
From page
141
To page
146
Abstract
Heavy metal accumulates mostly in mammalian liver and kidney as these organs involved in the detoxification and excretion of foreign materials. Chronic exposure of heavy metals leads to intoxication of these organs. In the present study sub-chronic effect of mercury (as mercuric chloride at a dose of 3.75 mg/kg body weight) on biochemical parameter was studied on the experimental animals. Results revealed that mercury increased the aspartate transpeptidase (AST), alanine transpeptidase (ALT), lactate dehydrogenase (LDH) and creatine phosphokinase (CPK) activities significantly than control group. This study also indicates that mercury increases the level of urea and creatinine; and decreases the iron level. Bioaccumulation of mercury was higher in kidney as compared to other organs
Keywords
Albino rats , mercuric chloride , sub , chronic toxicity , LD50R , RAST , ALT , LDH , CPK
Journal title
Jordan Journal of Biological Sciences
Journal title
Jordan Journal of Biological Sciences
Record number
2584808
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