Role of Melatonin and/or Vitamin B Complex against Hormonal Changes in Epinephrine-Stressed Rats

The current study aimed to investigate the effect of intramuscular injection of melatonin (MT)(1mg/ kg) and/or vitamin Bcomplex (Tri-B) (20 mg/kg) on the hormonal changes induced by Epinephrine (Epi) (0.02 mg/kg) in male albino rats. Intramuscular administration of Epi induced significant elevations in adrenocorticotropic hormone (ACTH), corticosterone (CORT), triiodothyronine (T3 ) and thyroxine (T4) 1 evels after the two experimental durations. On the other hand, luetinizing hormone (LH), testosterone , prolactin (PRL) and growth hormone (GH) levels were decreased under the same conditions. Melatonin treatment seems to constitute a selection therapy, by improving ATCH, CORT, T3 ,T4 and GH levels but has no effect on the low levels of LH , testosterone and PRL. Also, the data suggested that Tri-B injection partially improved the different endocrinological changes of Epi