Synthesis and Biological Evaluation of Certain New Substituted Pyrido[2,3-d]pyrimidin-4(1H)-one and Pyrido[2,3-d]triazolo[3,4-b]pyrimidine Analogs

The synthesis of a new series of Pyrido[2,3-d]-pyrimidine derivatives 8-13 and their corresponding S-methyl analogs 14-19 is described. The pyrido[2,3-d] triazolo[3,4-b]pyrimidines 26, 27 are also prepared. The structures of the newly synthesized compounds have been confirmed by elemental analysis, IR, and H-NMR spectra. DNA-binding activity of the synthesized compounds was performed.