Title of article
Cytotoxic and Anti-Inflammatory Activities of Garcinia xanthochymus Extracts on Cell Lines
Author/Authors
Hamidon, Hanisuhana International Islamic University Malaysia - Faculty of Pharmacy - Department of Pharmaceutical Technology, Malaysia , Taher, Muhammad International Islamic University Malaysia - Faculty of Pharmacy - Department of Pharmaceutical Technology, Malaysia , Jaffri, Juliana Md International Islamic University Malaysia - Faculty of Pharmacy - Department of Pharmaceutical Technology, Malaysia , Tg Zakaria, Tg Muhamad Faris Syafiq Faculty of Pharmacy - International Islamic University Malaysia - Department of Pharmaceutical Technology, Malaysia , Sulaiman, Wan MAW International Islamic University Malaysia - Faculty of Pharmacy - Department of Basic Medical Science, Malaysia , Susanti, Deny International Islamic University Malaysia - Faculty of Science - Department of Chemistry, Malaysia , Ichwan, Solachuddin JA International Islamic University Malaysia - Faculty of Dentistry, Malaysia , Zakaria, Zainul A Universiti Putra Malaysia - Faculty of Medicine and Health Science - Department of Biomedical Sciences, Malaysia
From page
11
To page
17
Abstract
Garcinia xanthochymus extract has been reported to have several pharmacological properties. This study was conducted to evaluate cytotoxic and anti-inflammatory activities of G. xanthochymus extracts on cell lines. Methods: The roots and stem barks of plant were extracted using maceration method with n-hexane, dichloromethane and methanol, successively. Cytotoxic activity of the extracts was tested against MCF-7 breast adenocarcinoma using MTT assay. Anti-inflammatory study was evaluated using RAW 264.7 mouse macrophage cells. The nitric oxide production in LPS-stimulated cells was measured using Griess reagent. Results: The results of cytotoxic and antiinflammatory study showed that dichloromethane and n-hexane extracts of root and stem bark exhibited cytotoxic activity in dose-dependent manner. Meanwhile, for anti-inflammatory study, all root extracts together with stem bark dichloromethane and n-hexane extracts reduce NO production in LPS-stimulated cells in dose dependent manner. Conclusions: This finding indicated that G. xanthochymus extracts might become interesting candidate for treatment of cancer and inflammation
Keywords
Garcinia xanthochymus , Guttiferae , cytotoxicity , anti , inflammatory , in vitro
Journal title
Makara Journal Of Health Research
Journal title
Makara Journal Of Health Research
Record number
2594916
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