Spectrophotometric Determination of Chlorpromazine – HCl Using Potassium Permanganate

Twosimple, sensitive,accurate, and precise spectrophotometric methods have been developed for the determination of chlorpromazine – HCl in pure form and pharmaceutical formulation. The first method involved treatment of cited drug with a measured excess of permanganate in acid medium and the unreacted oxidant was measured at 525 nm. The second method involves the reaction of the drug with potassium permanganate in the presence of sodium hydroxide to produce a bluish – green colored manganite which is measurable at 610nm. All the experimental variables affecting the development of the manganite ions were investigatedand conditions were optimized. Working linearity ranges were 5-45 μg.mL- 1and 1-20 μg.mL-1 by two methods respectively. The apparent molarabsorptivities are 4.015 x 103and 18.717x 103L.mol-1.cm-1 respectively, with corresponding Sandell’s sensitivityvalues of0.0885and 0.01798μg.cm-2 respectively. The methods have successfully been applied to the determinationof drug in dosage forms.