Title of article
Catalyst-Free One-Pot Four-Component Synthesis of 3-(Imino)-pyrrolo[2,1-a]isoquinolines in Glycerol: Two Different Products through Two Different Purification Methods
Author/Authors
Jehbez, S.A. Department of Applied Chemistry - Shiraz Branch, Islamic Azad University, Shiraz, Iran , Safaei, H. Department of Applied Chemistry - Shiraz Branch, Islamic Azad University, Shiraz, Iran , Shekouhy, M. Department of Applied Chemistry - Shiraz Branch, Islamic Azad University, Shiraz, Iran
Pages
12
From page
13
To page
24
Abstract
The one-pot four component synthesis of 3-(Imino)-2,3-dihydropyrrolo[2,1-a]isoquinoline-1,1(10bH)-dicarbonitrile derivatives via a catalyst-free reaction between aryl aldehydes, malononitrile, isoquinoline and isocyanides was successfully conducted in glycerol as a benign, nontoxic and biodegradable promoting reaction medium. The progress of the reaction with two different common purification methods were investigated. Moreover, synthesized products were examined as chemical sensors for the detection of a wide range of metal ions and it was successful for the detection of Co2+ ions.
Keywords
Multicomponent synthesis , In column chromatography reaction , Glycerol , Sustainable reaction medium , Isocyanide
Journal title
Organic Chemistry Research
Serial Year
2020
Record number
2608505
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