Atypical Myocardial Infarction with Apical Thrombus andSystemic Embolism: A Rare Presentation of Likely JAK2V617F-Positive Myeloproliferative Neoplasm

A few types of myeloproliferative neoplasms may be significant for Janus-associated kinase 2 mutation, JAK2 V617F, includingpolycythemia vera, essential thrombocythemia, and primary myelofibrosis. The prevalence of JAK2 mutation is low in thegeneral population but higher in patients with myeloproliferative neoplasms. Some patients with JAK2 V617F-positive essentialthrombocythemia are asymptomatic, but others may develop hemorrhagic or thromboembolic complications.Thromboembolism may occur in vessels of highflow organs like the heart and, thereby, present as myocardial infarction.Nonetheless, these patients are usually symptomatic with complaints of chest pain, for example. Atypical (asymptomatic)myocardial infarction with mild thrombocytosis may be thefirst clue for possible essential thrombocythemia with JAK2 V617F.In this report, we discuss a case of atypical (asymptomatic) myocardial infarction with secondary thromboembolism in a patientpositive for JAK2 V617F with a likely myeloproliferative neoplasm