Fatal Outcome of Imatinib in a Patient with IdiopathicHypereosinophilic Syndrome

Cytokine storm is a poorly explained clinical entity caused by an undesired and aggrandized immune system response leading tounregulated activation of the proinflammatory cascade, often contributing to multisystem organ failure and even death. Itspotentially diverse etiologies and sepsis-like presentation have made it even more challenging to diagnose, and so far, no well-established treatment protocol has been proposed. Its association with certain medications, especially with monoclonal antibodies,has well been reported in literature. To the best of our knowledge, so far, no previous case of cytokine storm associated withimatinib has been reported. We herein present a case report of a 77-year-old male with a past medical history of hypereosinophilicsyndrome who developed acute fatal cytokine storm following treatment with imatinib. (is study highlights a life-threateningcomplication of the medication that may be underrecognized.