Metastatic Breast Carcinoma to the Prostate Gland

Cancer of the male breast is an uncommon event with metastases to the breast occurring even less frequently. Prostate carcinomahas been reported as the most frequent primary to metastasize to the breast; however, the reverse has not been previously reported.Herein, we present, for the first time, a case of breast carcinoma metastasizing to the prostate gland. Prostate needle core biopsyrevealed infiltrative nests of neoplastic epithelioid cells, demonstrated by immunohistochemistry (IHC) to be positive for GATA3and ER and negative for PSA and P501S. A prostate cocktail by IHC study demonstrated lack of basal cells (p63 and CK903) andno expression of P501S. The patient’s previous breast needle core biopsy showed strong ER positivity and negative staining for PRand HER2. Similar to the prostate, the breast was negative forCK5/6, p63, and p40. This case demonstrates the importance ofconsidering a broad differential diagnosis and comparing histology and IHC to prior known malignancies in the setting of atypicalpresentation or rare tumors.