Cerebellar Ataxia Followed by Stiff Person Syndrome in aPatient with Anti-GAD Antibodies

Anti-GAD antibody syndrome is a result of the production of antibodies against glutamic acid decarboxylase (GAD), the mainenzyme responsible for the production of gamma-aminobutyric acid (GABA). Several neurological manifestations includingcerebellar ataxia and stiff person syndrome have been reported in association with anti-GAD antibodies. In this paper, we presenta case of a young woman with anti-GAD antibodies who initially presented with cerebellar ataxia followed by stiff personsyndrome three and a half years later. Having both cerebellar ataxia and stiff person syndrome is a rare occurrence in anti-GADantibody syndrome. We emphasise the importance of long-term follow-up of patients with anti-GAD antibody syndrome, asdelayed neurological manifestations can occur.