A Novel STAT3 Gene Mutation Related Hyper-IgE SyndromeMisdiagnosed as Hidradenitis Suppurativa

Although Hyper-IgE Syndrome (HIES) is a rare immunodeficiency disorder, presenting symptoms may be as common as lungand skin infections. Symptoms are usually nonspecific such as recurrent abscesses, folliculitis, and pneumonias along with skeletalabnormalities. Careful history of susceptibility to skin and lung infections, thorough family history, and findings on physical examcan guide towards the diagnosis of this often-eluded condition. Early optimization of therapy with prophylactic antibiotics canprevent recurrent infections and future complications and improve quality of life and longevity of survival. We present a case of ayoung female with Hyper-IgE Syndrome with a novel mutation in STAT 3 gene who initially presented with long standing historyof intractable skin abscesses being managed as Hidradenitis Suppurativa