Title of article
Cell wall inhibitors increase the accumulation of rifampicin in Mycobacterium tuberculosis
Author/Authors
McNeil, Matthew B. TB Discovery Research - Infectious Disease Research Institute, Seattle, WA, USA , Chettiar, Somsundaram TB Discovery Research - Infectious Disease Research Institute, Seattle, WA, USA , Awasthi, Divya TB Discovery Research - Infectious Disease Research Institute, Seattle, WA, USA , Parish, Tanya TB Discovery Research - Infectious Disease Research Institute, Seattle, WA, USA
Pages
5
From page
1
To page
5
Abstract
There is a need for new combination regimens for tuberculosis. Identifying synergistic drug combinations can avoid toxic side effects and reduce treatment times. Using a fluorescent rifampicin conjugate, we demonstrated that synergy between cell wall inhibitors and rifampicin was associated with increased accumulation of rifampicin. Increased accumulation was also associated with increased cellular permeability.
Keywords
mycobacteria , permeability , tuberculosis , rifampicin , Mycobacterium tuberculosis
Journal title
Access Microbiology
Serial Year
2019
Record number
2615627
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