Title of article
Phage Peptide Libraries As a Source of Targeted Ligands
Author/Authors
Nemudraya, A.A. Institute of Chemical Biology and Fundamental Medicine - Siberian Branch of the Russian Academy of Sciences, russia , Richter, V.A. Institute of Chemical Biology and Fundamental Medicine - Siberian Branch of the Russian Academy of Sciences, russia , Kuligina, E.V. Institute of Chemical Biology and Fundamental Medicine - Siberian Branch of the Russian Academy of Sciences, russia
Pages
10
From page
48
To page
57
Abstract
One of the dominant trends in modern pharmacology is the creation of drugs that act directly on the lesion focus and have minimal toxicity on healthy tissues and organs. This problem is particularly acute in rela-tion to oncologic diseases. Short tissue- and organ-specific peptides capable of delivering drugs to the affected organ or tissue are considered promising targeted agents that can be used in the diagnosis and therapy of dis-eases, including cancer. The review discusses in detail the technology of phage display as a method for obtaining specific targeted peptide agents and offers examples of their use in diagnostic and clinical practice.
Farsi abstract
فاقد چكيده فارسي
Keywords
targeted peptides , drug delivery , phage display , phage peptide libraries
Journal title
Acta Naturae
Serial Year
2016
Full Text URL
Record number
2615944
Link To Document