Title of article
1-(4-Phenoxybenzyl) 5-Aminouracil Derivatives and Their Analogues – Novel Inhibitors of Human Adenovirus Replication
Author/Authors
Nikitenko, N.A N.F. Gamaleya Federal National Research Center for Epidemiology and Microbiology, Moscow, Russia , Gureeva, E.S Volgograd State Medical University, Volgograd, Russia , Ozerov, A.A Volgograd State Medical University, Volgograd, Russia , Tukhvatulin, A.I Volgograd State Medical University, Volgograd, Russia , Izhaeva, F.M N.F. Gamaleya Federal National Research Center for Epidemiology and Microbiology, Moscow, Russia , Prassolov, V.S Engelhardt Institute of Molecular Biology - Russian Academy of Sciences, Moscow, Russia , Deryabin, P.G N.F. Gamaleya Federal National Research Center for Epidemiology and Microbiology, Moscow, Russia , Novikov, M.S Volgograd State Medical University, Volgograd, Russia , Logunov, D.Y N.F. Gamaleya Federal National Research Center for Epidemiology and Microbiology, Moscow, Russia
Pages
7
From page
58
To page
64
Abstract
Adenovirus infections are characterized by widespread distribution. The lack of causal therapy, which is effective in treating this group of diseases, explains the need for new therapeutic drugs. Notably, anti-adenovi-ral activity of [4-(phenoxy)benzyl]-5-(phenylamino)-6-azauracil, 1-[4-(phenoxy)benzyl]-5-(morpholino) uracil, 1-[4-(4-chlorophenoxy)benzyl]-5-(morpholino) uracil, and 1-[4-(4-fluorophenoxy)-benzyl]-5-(morpholino) uracil was observed.
Keywords
inhibitors of adenovirus replication , adenovirus replication , 5-aminouracil derivatives , Human adenovirus
Journal title
Acta Naturae
Serial Year
2018
Full Text URL
Record number
2616122
Link To Document