• Title of article

    Serological under expression of microRNA-21, microRNA-34a and microRNA-126 in colorectal cancer

  • Author/Authors

    Almeida, Ana Luiza Normanha Ribeiro de Department of Surgery and Anatomy - Ribeirão Preto Medical School - University of São Paulo, Brazil , Bernardes, Mário Vinícius Angelete Alvarez Department of Surgery and Anatomy - Ribeirão Preto Medical School - University of São Paulo, Brazil , Feitosa, Marley Ribeiro Department of Surgery and Anatomy - Ribeirão Preto Medical School - University of São Paulo, Brazil , Peria, Fernanda Maris Ribeirão Preto Medical School - University of São Paulo, Brazil , Tirapelli, Daniela Pretti da Cunha Department of Surgery and Anatomy - Ribeirão Preto Medical School - University of São Paulo, Brazil , Rocha, José Joaquim Ribeiro da Department of Surgery and Anatomy - Ribeirão Preto Medical School - University of São Paulo, Brazil , Feres, Omar Department of Surgery and Anatomy - Ribeirão Preto Medical School - University of São Paulo, Brazil

  • Pages
    6
  • From page
    13
  • To page
    18
  • Abstract
    PURPOSE: This paper describes the ability of miRNA value predict oncological outcomes in CRC patients and correlates to clinical and pathologic variables. METHODS: We prospectively analyzed the serological expression of microRNA-21, microRNA-34a, and microRNA-126 in 37 stage II - IV CRC patients and correlate to seven fit counterparts. Serological microRNAs were extracted using the miRNeasy Mini Kit(r) (Qiagen, Hilden, Germany). Quantification of microRNAs was performed using TaqMan Master Mix(r) reagent (Applied Biosystems, USA). RESULTS: We obtained serological underexpression microRNA-21, microRNA-34a, and microRNA-126 in CRC group. However, miRNAs serological values do not impact prognosis. Furthermore, miRNAs was not influenced by CEA values, TNM staging, and histological subtype. CONCLUSION: Despite lower expression of miR-21, miR-34a and miR-126 in the CRC group, no association with poor prognosis was found.
  • Keywords
    Colonic Neoplasms , Colon , Drug Therapy , MicroRNAs , Serum
  • Journal title
    Acta Cirurgica Brasileira
  • Serial Year
    2016
  • Full Text URL
    www.scielo.br/j/acb/a/67xSLnkt545q5K7PMBqyPLD/?format=pdf&lang=en
  • Record number

    2616471

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=2616471