Title of article
Synthesis and Antiviral Properties of 1-Substituted 3-[ω-(4-Oxoquinazolin-4(3H)-yl)alkyl]uracil Derivatives
Author/Authors
Paramonova, M.P Department of Pharmaceutical & Toxicological Chemistry - Volgograd State Medical University, Volgograd, Russia , Khandazhinskaya, A.L Engelhardt Institute of Molecular Biology - Russian Academy of Science, Moscow, Russia , Ozerov, A.A Department of Pharmaceutical & Toxicological Chemistry - Volgograd State Medical University, Volgograd, Russia , Kochetkov, S.N Engelhardt Institute of Molecular Biology - Russian Academy of Science, Moscow, Russia , Snoeck, R Rega Institute for Medical Research, KU Leuven, B-3000 Leuven, Belgium , Andrei, G Rega Institute for Medical Research, KU Leuven, B-3000 Leuven, Belgium , Novikov, M.S Department of Pharmaceutical & Toxicological Chemistry - Volgograd State Medical University, Volgograd, Russia
Pages
6
From page
134
To page
139
Abstract
series of uracil derivatives containing a 4-oxoquinazoline fragment bound to the nitrogen atom N3 of the pyrimidine ring by a short methylene bridge was synthesized to search for new antiviral agents. Some compounds in this series are shown to exhibit high inhibitory activity against human cytomegalovirus and the varicella zoster virus in a HEL cell culture.
Keywords
varicella zoster virus , human cytomegalovirus , antiviral activity , synthesis , 4-oxoquinazoline , Uracil derivatives
Journal title
Acta Naturae
Serial Year
2020
Record number
2617336
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