• Title of article

    Malignant Neuroleptic Syndrome following Deep Brain Stimulation Surgery of Globus Pallidus Pars Internus in Cerebral Palsy

  • Author/Authors

    Lee, Jae Meen Department of Neurosurgery - Seoul National University Hospital - Seoul, Korea , Paek, Sun Ha Department of Neurosurgery - Seoul National University Hospital - Seoul, Korea , Park, Hye Ran Department of Neurosurgery - Seoul National University Hospital - Seoul, Korea , Lee, Kang Hee Department of Anesthesiology - Seoul National University Hospital - Seoul, Korea , Shin, Chae Won Department of Neurology - Seoul National University Hospital - Seoul, Korea , Park, Hye Young Department of Neurology - Seoul National University Hospital - Seoul, Korea , Park, Hee Pyoung Department of Anesthesiology - Seoul National University Hospital - Seoul, Korea , Kim, Dong Gyu Department of Neurosurgery - Seoul National University Hospital - Seoul, Korea , Jeon, Beom Seok Department of Anesthesiology - Seoul National University Hospital - Seoul, Korea

  • Pages
    5
  • From page
    34
  • To page
    38
  • Abstract
    Neuroleptic malignant syndrome (NMS) is a rare but potentially lethal outcome caused by sudden discontinuation or dose reduction of dopaminergic agents. We report an extremely rare case of NMS after deep brain stimulation (DBS) surgery in a cerebral palsy (CP) patient without the withdrawal of dopaminergic agents. A 19-year-old girl with CP was admitted for DBS due to medically refractory dystonia and rigidity. Dopaminergic agents were not stopped preoperatively. DBS was performed uneventfully under monitored anesthesia. Dopaminergic medication was continued during the postoperative period. She manifested spasticity and muscle rigidity, and was high fever resistant to anti-pyretic drugs at 2 h postoperative. At postoperative 20 h, she suffered cardiac arrest and expired, despite vigorous cardiopulmonary resuscitation. NMS should be considered for hyperthermia and severe spasticity in CP patients after DBS surgery, irrespective of continued dopaminergic medication.
  • Keywords
    cerebral palsy , deep brain stimulation , neuroleptic malignant syndrome
  • Journal title
    Acute and Critical Care
  • Serial Year
    2016
  • Full Text URL
    upload/pdf/kjccm-2016-31-1-34.pdf
  • Record number

    2621518

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=2621518