Title of article
Melanin and lipofuscin as hallmarks of skin aging
Author/Authors
Skoczyńska, Anna Department of Cosmetic Raw Materials Chemistry - Medical University of Lodz, Poland , Budzisz, Elżbieta Department of Cosmetic Raw Materials Chemistry - Medical University of Lodz, Poland , Trznadel-Grodzka, Ewa Department of Dermatology and Pediatric Dermatology - Medical University of Lodz, Poland , Rotsztejn, Helena Department of Cosmetology and Aesthetic Dermatology - Medical University of Lodz, Poland
Pages
7
From page
97
To page
103
Abstract
Discoloration are symptoms of skin aging. They are connected with presence of melanin and lipofuscin, whose excess and abnormal distribution in the skin cause dark spots to appear. Melanin is formed under the influence of tyrosinase during melanogenesis. Its content changes with age, which may be a result of menopause. Lipofuscin is another example of the age pigment. It is composed of proteins, lipids and carbohydrates. It is described as an age pigment because its content increases with age. The formation and accumulation of lipofuscin is inevitable and leads to cell and homeostasis dysfunction because it reduces the proteasome activity.
Keywords
melanin , lipofuscin , melanogenesis , lipofuscinogenesis , pigments , skin aging
Journal title
Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii
Serial Year
2017
Record number
2622791
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