We need well-designed multicenter studies to investigate neurologic manifestations of coronavirus disease 2019

Early reports of coronavirus disease 2019 (COVID-19) infection from China and other parts of the world emphasized that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily infected the respiratory system leading to serious cardiorespiratory complications such as acute respiratory distress syndrome (ARDS). However, according to recent reports, coronaviruses could involve the central nervous system (CNS) and peripheral nervous system (PNS).1-5 Both acute and chronic infections with SARS-CoV-2 could affect the nervous system. Encephalitis, acute reactive seizures and status epilepticus, acute disseminated encephalomyelitis (ADEM), and Guillain-Barre syndrome (GBS) have been reported as neurologic manifestations of coronavirus infection. After infection by the Middle East respiratory syndromerelated coronavirus (MERS-CoV), a number of neurologic complications such as mental status changes, ataxia, focal motor deficits, and Bickerstaff encephalitis have been described. In children, seizures and meningoencephalitis have been reported after infection with human coronaviruses.1-6