Hydroxyurea – An experience in the management of psoriasis

Objective: To assess efficacy and safety of hydroxyurea therapy in different types of psoriasis. Patients and methods: Eighty patients of chronic plaque psoriasis, generalized pustular psoriasis with more than 20% body surface area and psoriatic erythroderma were included in the prospective nonrandomized study. Results: At least good response (up to 50% reduction of PASI) to therapy was noticed in 77.6% (59/76), 11.9% patients did not respond and 10.5% patients worsened. Conclusion: Hydroxyurea is effective in the treatment of extensive psoriasis with not so serious side effects.