STUDY THE INH INHIBITORY EFFECT OF Lactobacillus acidophilus ISOLATED FROM YOGHURT AS PROBIOTICS ON Candida albicans GROWTH IN VITRO AND IN VIVO

This research was designed to study the inhibitory effect of Lactobacillus acidophilus which has been isolated from yoghurt as probiotics in reduction of Candida albicans growth in vitro and in vivo. The results showed that the Minimum Inhibitory Concentrations and Minimum Fungicidal Concentrations were 60% and 70% respectively, also the inhibition zone of L. acidophilus against C. albicans reached to 26mm in solid medium .The out come of in vivo study (histological examination ) clarified that C. albicans caused clinical pathological effect in mice tissue organs ( liver , intestine, stomach , kidney) when administrated orally by 1.5x 10 8 cfu ml C. albicans that effect decrease by orally inoculated with same dose of L. acidophilus.The results reflect the ability of L. acidophilus to reduce certain clinical pathological change in mice organs, with promising encourage to use the L. acidophilus as biotherapeutic agents against C. albicanas infections.