Title of article
Carrier detection of phenylketonuria in Iranian families by variable number tandem-repeat polymorphism analysis
Author/Authors
Hosseini-Mazinani, S.M. National Research Centre for Genetic Engineering and Biotechnology, ايران , Koochmeshgi, J. National Research Centre for Genetic Engineering and Biotechnology, ايران , Koochmeshgi, J. Research Institute for Life, ايران , Khazaee-Koohpar, Z. National Research Centre for Genetic Engineering and Biotechnology, ايران , Hosein Pur-Nobari, N. National Research Centre for Genetic Engineering and Biotechnology, ايران , Hosein Pur-Nobari, N. Research Institute for Life, ايران , Seifati, S.M. Research Institute for Life, ايران , Seifati, S.M. National Research Centre for Genetic Engineering and Biotechnology, ايران
From page
1445
To page
1451
Abstract
This study of Iranian families assessed the usefulness of carrier detection of phenylketonuria by variable number tandem-repeat (VNTR) polymorphism analysis. We studied 171 people (45 unrelated PKU subjects, and their parents and unaffected siblings). Of 342 chromosomes (131 non-PKU and 211 PKU), 5 VNTR alleles were identified. This VNTR system would yield a polymorphism information content of 66%, comparable to that in Europeans and higher than in Chinese. Carrier detection by segregation analysis of VNTR was informative in 89.5% of siblings. We conclude that this polymorphism is highly informative in carrier detection of PKU in the Iranian population.
Journal title
Eastern Mediterranean Health Journal
Journal title
Eastern Mediterranean Health Journal
Record number
2640143
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