Title of article
Study of aerobic granulocyte functional activity in the presence of a radiosensitizer (metronidazole)
Author/Authors
Al-Krawi, E.A.A. University of Basra - Basra College of Medicine - Department of Pharmacology, Iraq , Al-Hashimi, A.H.M. University of Basra - Basra College of Medicine - Department of Physiology, Iraq
From page
224
To page
229
Abstract
The in vitro effects of metronidazole on the production of reactive oxygen species by polymorphonuclear (PMN) cells were studied by means of nitroblue tetrazolium and luminol-dependent chemiluminescence. At therapeutic doses of metronidazole (4.98–24.86 μg/mL) significant inhibition of the production of reactive oxygen species was noted in both methods. The inhibitory effect was in a dose-dependent pattern. The data suggest a scavenging mechanism of metronidazole on reactive oxygen species generated by PMN.
Journal title
Eastern Mediterranean Health Journal
Journal title
Eastern Mediterranean Health Journal
Record number
2640313
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