Title of article
DEVELOPMENT AND EVALUATION OF THE SINOMENINE TRANSDERMAL PATCH
Author/Authors
WANG, JIANPING Huazhong University of Science and Technology - School of Pharmacy, Tongji Medical Center, China , RUAN, JINLAN Huazhong University of Science and Technology - School of Pharmacy, Tongji Medical Center, China , ZHANG, CHANGGONG Huazhong University of Science and Technology - School of Pharmacy, Tongji Medical Center, China , YE, YUJIE Wuhan University of Science and Technology - Medical College, China , CAI, YALING Huazhong University of Science and Technology - School of Pharmacy, Tongji Medical Center, China , WU, YUNXIA Huazhong University of Science and Technology - School of Pharmacy, Tongji Medical Center, China
From page
407
To page
410
Abstract
Sinomenine transdermal patch was prepared and its properties were studied. The patches were produced by salivation method. The releasing rate in vitro of the patch was determined by HPLC. Peel test was used to evaluate the adhesion. Acute skin irritation test was performed in comparison with formalin (0.8%) by using mouse model. The Sinomenine TDDS Patch was prepared. The releasing rate in vitro followed the Higuchi equation (r 0.99), the releasing amount was beyond 90% in 24h. The peel adhesion to steel (N/25 mm) is 10 or above. The skin irritation tests showed negligible erythema and edema. The Sinomenine transdermal patch was prepared successfully and it may be beneficial for topical use.
Keywords
Sinomenine , transdermal patch , peel test , skin irritation test
Journal title
Pakistan Journal Of Pharmaceutical Sciences
Journal title
Pakistan Journal Of Pharmaceutical Sciences
Record number
2647078
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