Title of article
Anti-proliferation effect of Hevea brasiliensis latex B-serum on human breast epithelial cells
Author/Authors
Lee, Yang Kok Universiti Sains Malaysia - 1Centre for Drug Research (CDR), Malaysia , Lay, Lam Kit Universiti Sains Malaysia - Institute for Research in Molecular Medicine (INFORMM), Malaysia , Mahsufi, Mansor Sharif Universiti Sains Malaysia - Centre for Drug Research (CDR), Malaysia , Guan, Teoh Siang Universiti Sains Malaysia - School of Chemical Sciences, Malaysia , Elumalai, Sunderasan Rubber Research Institute of Malaysia, Malaysia , Thong, Ong Ming Universiti Sains Malaysia - Institute for Research in Molecular Medicine (INFORMM), Malaysia
From page
645
To page
650
Abstract
The rubber tree (Hevea brasiliensis) extracts are becoming increasingly visible in pharmaceutical and therapeutical research. The present study is aimed at examining the specific anti-proliferation property of H. brasiliensis latex B-serum sub-fractions against human breast cancer epithelial cell lines MCF-7 and MDA-MB231. The results showed that the latex whole B-serum and DBP sub-fraction exerted a specific anti-proliferation activity against cancerorigin cells MDA-MB231 but had little effect on non-cancer-origin cells. On the other hand, the anti-proliferative activity was diminished in the pre-heated B-serum fractions. With the low toxicity that the B-serum demonstrated previously in Brine Shrimp Lethality Test (BSLT), the present results suggest the potential use of the B-serum subfractions in cancer treatment.
Keywords
Hevea brasiliensis , B , serum , anti , cancer , breast cancer, epithelial cells.
Journal title
Pakistan Journal Of Pharmaceutical Sciences
Journal title
Pakistan Journal Of Pharmaceutical Sciences
Record number
2647588
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