Pharmacokinetics of fexofenadine in healthy Taiwanese volunteers

The aim of presented study was to assess pharmacokinetic properties of fexofenadine in Taiwanese volunteers. Thirty-three healthy male subjects received 180mg fexofenadine. Blood samples were drawn at appropriate times. Drug concentrations of fexofenadine were measured by a LC/MS/MS method. Non-compartmental models were applied to describe the pharmacokinetic characters of fexofenadine. After oral administration of fexofenadine, the Tmax was 1.90±0.81h. The Cmax was 703.76±298.94ng/mL and AUC0-∞ was 4582.52±1812.59h×ng/mL. The elimination half-life of fexofenadine was 12.18±3.61h. One of the most important determinants was to prove the similar results in the pharmacokinetics of fexofenadine in Taiwan subjects compared with the reported data of other ethnic origin.