Effect of Mulberry crud extract as antioxidant and antiatherogenic experimentally on rabbit

This study was conducted to explore the ability of mulberry( Morus albas L.) cold and boild crud equeous extract as antioxidant and antiatherogenic in rabbit after exposure to 0.5% H2O2 in drinking water for 30 days. The results illustrated capability of 0.5%H2O2 to initiate oxidative stress via significant increase in malondialdihyde (MDA) level in heart and liver concomitant with significant decrees in Glutathione (GSH) in addition to decreas in high density lipoprotein-c HDL and increase in low density lipoprotein-c (LDL-c) in serum of treated rabbits. While rabbit treated with H2O2 associated with mulberry leaves (cold and boild aqueous crud extract) showed a significant increase in GSH concentration of liver and heart tissue as well as increase in HDL-c, decrees in LDL-c and atherogenic index. Histologically, heart, aorta showed less reduction in lipid vacuol and proliferation of vascular smooth muscle cell in media toward intima, but it is not reach to normal picture in rabbit treated with mulberry (Morus albas L.) while liver sections showed some vacuolar degeneration.