Protective Effect of Aspirin in Relation to IGF-1 in Streptozotocin Induced Type-II Diabetic Rats

The present study aimed at investigating the protective effects of aspirin in rela-tion to insulin like growth factor-1 (IGF-1) in streptozotocin (STZ) induced type-2 diabetic rats.Materials and Methods: Rat pups were divided into four groups; on the 5th day of their age, group-I pups received citrate buffer solution and served as the normal group; group-II, treated on-ly with streptozotocin (80 mg/kg, i.p), served as the diabetic group; groups-III IV, treated with aspirin (10 mg/kg/day, p.o) for one month (5-35 days) and two months (5-65 days) after streptozo-tocin, served as the treated groups. On the 35th and 65th days, blood samples were collected from all animals and fasting blood sugar, fasting insu-lin, IGF-1, insulin resistance and insulin sensi-tivity levels were estimated. Results: UConclusions:U The study indicates that aspirin pretreatment seems to protect the pancreas from damage caused by STZ and maintains glucose levels in diabetic rats, while increasing insulin sensitivity and reducing insulin resistance, which may indicate an involvement of an insulin like pathway, particularly IGF-1.