EFFECT OF SUBMINIMAL INHIBITORY CONCENTRATION OF GENTAMICIN ON THE PATHOGENICITY OF ESCHERICHIA COLI CAUSING INFANTILE DIARRHOEA

One hundred patient infant complaining from infantile diarrhoea were studied, the percentage of E. coli infection was 24%. The in vitro adherence test was done to determine the adhesion capacity of bacteria to Human Buccal Epithelial Cells (HBECs). The result shows, increasing in the mean adhesion of E. coli as compared with the control group. Minimal Inhibitory Concentration (MIC) and sub Minimal Inhibitory Concentration (subMIC) of gentamicin was done to study the effect of subMIC of this antibiotic on the adhesion , the result shows that the using of gentamicin in lower doses (subMIC) decreases the adhesion capacity of bacteria .EPEC still mediclly important as a danger pathogen especially in poorly hyagiene communities such as Iraqi community