Synthesis and Characterization of some Oxadiazoles and Thiadiazoles derivatives

A number of heterocyclic compounds was synthesized from the reaction of methyl benzoate (1) withhydrazine hydrate in the presence of alcohol to give phenyl hydrazide (2).The phenyl hydrazide (2) had been treated with various aromatic aldehydes in absolute ethanol yield corresponding Schiff bases (4a – g), and these compounds were treated with acetic anhydride to give (5a – g).Phenyl hydrazide (2) was treated with Carbon disulfide in alcoholic Potassium hydroxide solution to give (3) and the reaction of (3) with hydrazine hydrate give substituted -1, 2, 4- triazole (6). Finally the reaction of (3) with various Aryl halides in the presence of alcoholic Potassium hydroxidesolution gave substituted -1, 3, 4- Oxadiazole -2- Aryl thioether (7a – g).The synthesized compounds were identified by physical, chemical and spectroscopic data.